Albert Einstein's brain floats in a Tupperware bowl in a gray duffel bag in the trunk of a Buick Skylark barreling across America. Driving the car is journalist Michael Paterniti. Sitting next to him is an eighty-four-year-old pathologist named Thomas Harvey, who performed the autopsy on Einstein in 1955 -- then simply removed the brain and took it home. And kept it for over forty years.

On a cold February day, the two men and the brain leave New Jersey and light out on I-70 for sunny California, where Einstein's perplexed granddaughter, Evelyn, awaits. And riding along as the imaginary fourth passenger is Einstein himself, an id-driven genius, the original galactic slacker with his head in the stars. Part travelogue, part memoir, part history, part biography, and part meditation, Driving Mr. Albert is one of the most unique road trips in modern literature.